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Molecular sieves are materials with pores of uniform size and diameter that are similar in size to small molecules; used to separate molecules by size; available in various pore size ranges, with drying solvent indicators, etc.
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Nutlin-3a is a small-molecule MDM2 antagonist used in research to activate wild-type p53, stabilize p53 protein, and induce apoptosis and autophagy. It is intended for laboratory research use and is characterized for cell-based and biochemical assays.
Inhibits MDM2-p53 interaction, leading to p53 activation.
Induces apoptosis and autophagy in p53 wild-type cells.
High reported purity (≈99.1%) suitable for research applications.
Molecular formula C30H30Cl2N4O4 and molecular weight ~581.5 g/mol.
Available in multiple solid and solution sizes for experimental flexibility.
For research use only; not for human or animal therapeutic use.
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TCS-PIM-1-4a is a small-molecule inhibitor targeting Pim kinases a family of serine/threonine kinases It is designed to selectively inhibit Pim kinases thereby modulating signaling pathways related to cell growth and survival TCS-PIM-1-4a exerts its biological activity primarily through activation of AMP-activated protein kinase (AMPK) resulting in inhibition of the mammalian target of rapamycin complex 1 (mTORC1) signaling pathway In cell-based studies TCS-PIM-1-4a demonstrates cytotoxic activity against diverse hematological tumor cell lines including myeloid and lymphoid subtypes with IC50 values ranging from approximately 0 8 to 40 M Based on these pharmacological properties TCS-PIM-1-4a holds research potential in investigations of Pim kinase signaling and therapeutic strategies for hematological malignancies
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Regeneration or ActivationA saturated molecular sieve can be restored to its original capacity by regeneration the principle of which involves changing the conditions surrounding the adsorbent to correspond to a very low equilibrium capacity. In general the greater the difference between the equilibrium capacities of adsorption and regeneration the more rapid and complete the regeneration.The sieve may be regenerated in one of four ways1. Thermal reactivation -The maximum regeneration temperature for Silica is 300C.2. Pressure reactivation3. Passing an appropriate fluid through the gel bed at normal temperature and pressure.4. Displacement of adsorbates by passing a high concentration of molecules in a fluid through the bed.
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
TCS-PIM-1-4a is a small-molecule inhibitor targeting Pim kinases a family of serine/threonine kinases It is designed to selectively inhibit Pim kinases thereby modulating signaling pathways related to cell growth and survival TCS-PIM-1-4a exerts its biological activity primarily through activation of AMP-activated protein kinase (AMPK) resulting in inhibition of the mammalian target of rapamycin complex 1 (mTORC1) signaling pathway In cell-based studies TCS-PIM-1-4a demonstrates cytotoxic activity against diverse hematological tumor cell lines including myeloid and lymphoid subtypes with IC50 values ranging from approximately 0 8 to 40 M Based on these pharmacological properties TCS-PIM-1-4a holds research potential in investigations of Pim kinase signaling and therapeutic strategies for hematological malignancies
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Dodeca-2E 4E 8Z 10Z/E-N-tetraenoic acid isobutylamide is a brain-penetrant substance and the main alkamide in Echinacea preparations which might be used for research of common cold and various upper respiratory infections[1]
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4alpha-phorbol 12-myristate 13-acetate is the inactive stereoisomer of TPA used as a negative control in experiments that monitor TPA-activated signaling events. It is supplied as a high-purity research reagent in a small-mass vial suitable for in vitro assays.
Inactive negative control for TPA-activated events.
High purity (99.0%) for reproducible results.
Molecular formula C36H56O8 and molecular weight 616.83 for accurate identification.
Supplied in a 1 mg package suitable for small-scale studies.
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